We have reduced our usage and completely closed our dogs facility. Maintaining animal colonies is very expensive, so there’s a big cost saving there.
The TIM-1 correctly predicted in vivo rank order in 84% and 79% of cases for AUC and Cmax, respectively…
Barker et al., J. Pharm. Sci. 103 (11): 3704-3712. doi: 10.1002/jps.24177.
Glaxo Smith Kline
The use of the TIM1 model in conjunction with GastroPLUS™ software provides an excellent tool to aid formulation selection based on improved estimates of the in vivo performance of oral dosage delivery formulations.
Naylor et al., Applied Therapeutic Research 6 (1): 15-19
…examples suggest that the TIM-1 system, which provides an advanced level of control over a dynamic and complex luminal environment, may have several advantages over conventional dissolution methodologies when assessing the performance of dosage forms in either the fasted or fed states.
McAllister et al., Mol. Pharm. 7 (5): 1374-1387.
Using the more sophisticated TIM-1 model, which is an in vitro model that allows the closest simulation of in vivo dynamic physiological processes occurring in the lumen of the stomach currently available, we confirm that lycopene does not undergo isomerisation in the gastrointestinal tract.
Richelle et al., Br. J. Nutr. 103: 1800-1807.