ACCELERATING (PRE)CLINICAL DEVELOPMENT
The TIM technology was introduced 30 years ago and has been further developed, currently representing the most advanced dynamic in vitro GI model available.
By employing a proprietary in vitro technology called TIM, TIM Studies have changed what’s possible with accurate predictions of the bioaccessibility of oral drug or food candidates.
“Multiple candidate formulations can be tested in a relative short period of time at a fraction of the cost of a clinical study” – Pfizer
Scientists now have alternatives to relying solely on animal studies or traditional dynamic dissolution methods, which typically show moderate in vitro-in vivo correlations of around ~.5
TIM Studies exceed in predicting in vivo behaviour of novel formulations and drug products during transit in the gastrointestinal tract, with ~.9 In vitro-in vivo correlations.